Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline.

ABSTRACT:

Background

High blood pressure (BP) is a known risk factor for cognitive decline and dementia, but the underlying mechanisms are largely unknown. We investigated the associations of cumulative BP exposure with hippocampal subfield volume and cognitive function and determined whether hippocampal subfield atrophy mediates the association between cumulative BP exposure and cognitive decline.

Methods

Between December 2020 and March 2023, participants were prospectively included from the Kailuan study. The cumulative BP was calculated as the area under the curve (mm Hg×years) using measurements from 2006 to 2023. A brain magnetic resonance imaging and the Montreal Cognitive Assessment was conducted beginning in 2020. The hippocampus was automatically segmented into 12 subfields v

SUBMITTER: Li X 

PROVIDER: S-EPMC12554414 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature