Associations Between Hematologic Parameters and All-Cause Death in Individuals With Cardio-Renal-Metabolic Multimorbidity: A National Cohort Study.

ABSTRACT:

Background

Cardio-renal-metabolic multimorbidity is common and a major cause of death. This study investigates the associations between hematologic parameters and all-cause death, aiming to redefine complete blood count reference intervals for individuals with cardio-renal-metabolic multimorbidity.

Methods

The study cohort consisted of 4482 adults drawn from the National Health and Nutrition Examination Survey conducted between 1999 and 2018. To assess the associations of hemoglobin concentration, platelet count, white blood cell count, and systemic inflammatory response index with the risk of all-cause death, multivariable Cox regression and restricted cubic spline regression analyses were used. Subgroup and sensitivity analyses were performed to ensure the robustness of th

SUBMITTER: Wen S 

PROVIDER: S-EPMC12554417 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature