Association between the triglyceride-glucose-waist-to-height ratio and cardiovascular disease in Chinese adults with sarcopenia or probable sarcopenia.

ABSTRACT:

Introduction

Sarcopenia, an age-related syndrome characterized by decreased muscle mass and performance, has been increasingly linked to high cardiovascular disease (CVD) risk. In this study, sarcopenia and probable sarcopenia were diagnosed according to the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. However, specific biomarkers underlying this association, such as the triglyceride-glucose-waist-to-height ratio (TyG-WHtR), remain unclear.

Methods

A cohort of 2,521 adults ≥45 years with sarcopenia or probable sarcopenia (2011-2020) were stratified by TyG-WHtR tertiles: T1 (≤4.30), T2 (4.30-5.01), and T3 (>5.01). To quantify the predictive utility of TyG-WHtR for CVD, methods such as Cox proportional hazards models, restricted cubic splines, and threshold regress

SUBMITTER: Huang W 

PROVIDER: S-EPMC12554443 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature