Effects of drospirenone and ethinylestradiol tablets (II) combined with metformin on the composition of gut microbiota in polycystic ovary syndrome with insulin resistance.

ABSTRACT:

Objectives

To explore the relationship between polycystic ovary syndrome with insulin resistance (PCOS-IR) and gut microbiota by analyzing the composition characteristics of gut microbiota in PCOS without or with Insulin resistance (IR) and the changes before and after treatment.

Methods

Women with PCOS were recruited and divided into polycystic ovary syndrome without insulin resistance (PCOS-NIR) group and PCOS-IR group. The PCOS-NIR group was given oral drospirenone and ethinylestradiol tablets (II), and the PCOS-IR group was given oral drospirenone and ethinylestradiol tablets (II) combined with metformin hydrochloride tablets. The course of treatment was 3 months. Baseline data, blood and stool samples were collected before and after treatment. All those stool samples we

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12554447 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature