Real-time prognosis prediction with conditional survival analysis for skull base chordoma based on SEER.

ABSTRACT:

Background

Skull base chordoma (SBC) is a rare, locally aggressive malignant bone tumor with a poor prognosis due to its location and recurrence. Despite advances in surgery and radiotherapy (RT), long-term survival remains uncertain. Traditional survival analyses are limited by their static nature, failing to capture the dynamic changes in survival probabilities over time. To address this, we applied conditional survival (CS) analysis for more precise evaluation of evolving survival rates in SBC patients.

Methods

Data of 717 SBC patients [2000-2019] from SEER (Surveillance, Epidemiology, and End Results) database were obtained. Using CS analysis, we evaluated survival probabilities over time and developed the first SBC-specific CS-nomogram. Key clinicopathological factors w

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12554463 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature