TFP12 as a key regulator of sentinel lymph node metastasis in breast cancer.

ABSTRACT:

Background

Breast cancer remains one of the most prevalent malignancies worldwide, with sentinel lymph nodes (SLNs) serving as critical gateways for early metastasis. While SLN status is routinely used for clinical staging, the molecular features of SLN-associated genes and their prognostic significance are not fully understood. This study elucidates the functional roles of SLN-associated genes in breast carcinogenesis, establishing a molecular subtyping framework with prognostic significance through integrated multi-omics analysis.

Methods

Differential expression analysis utilizing high-throughput sequencing was conducted to identify SLN-associated genes. Additionally, Molecular subtyping was performed through ConsensusClusterPlus, followed by implementation of a least abso

SUBMITTER: An A 

PROVIDER: S-EPMC12554470 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature