An immune-related miRNA signature predicts the prognosis in nasopharyngeal carcinoma.

ABSTRACT:

Background

MicroRNAs (miRNAs) play a significant role in the progression of nasopharyngeal carcinoma (NPC), particularly in relation to immune responses. This study aims to identify immune-related miRNAs that contribute to the development of a prognostic signature for overall survival (OS) in NPC patients.

Methods

Differentially expressed miRNAs between NPC and normal nasopharyngeal tissues were identified using GSE70970, GSE32960, and The Cancer Genome Atlas (TCGA)-NPC datasets. Univariate Cox regression analysis was performed to find miRNAs associated with OS. The Least Absolute Shrinkage and Selection Operator algorithm was conducted on the GSE70970 cohort to create a risk signature, stratifying patients into high- and low-risk groups based on the median risk score.

Re

SUBMITTER: Wang S 

PROVIDER: S-EPMC12554472 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature