PARP-1 in tumor complicated with depression-possible role and therapeutic perspective: a narrative review.

ABSTRACT:

Background and objective

Psycho-oncology examines the psychological dimensions of cancer, particularly depression and anxiety, which are more prevalent among cancer patients than the general population. The coexistence of depression and cancer can exacerbate cancer progression, increase healthcare costs, and diminish patients' quality of life. Poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme critical for DNA damage repair, is overexpressed in various tumors and associated with tumor progression. Emerging evidence suggests that PARP inhibitors may improve depression, highlighting PARP-1 as a potential therapeutic target for cancer-depression comorbidity. This review explores the role of PARP-1 in the mechanisms underlying cancer-depression comorbidity and its therapeutic potential.

SUBMITTER: Qin J 

PROVIDER: S-EPMC12554476 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature