Prospective proteomics for discovering biomarkers in lung adenocarcinoma: a literature review.

ABSTRACT:

Background and objective

Lung adenocarcinoma (LUAD), as the main subtype of non-small cell lung cancer (NSCLC), faces clinical challenges including molecular heterogeneity, late diagnosis, and aggressive growth, leading to a low 5-year survival rate. Biomarkers are critical for early detection, accurate differentiation of benign/malignant lesions, and guiding personalized treatment strategies. Proteomic technologies using liquid biopsy show potential by analyzing protein changes and post-translational modifications (PTMs) to identify novel biomarkers and unravel cancer mechanisms. This review examines proteomic advances in LUAD, compares platform strengths, lists validated protein markers, and discusses challenges like specificity and regulations. It aims to develop a precision med

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12554480 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature