Prognostic and predictive roles of circulating microRNAs as biomarkers in head and neck cancer patients in the Northern Territory, Australia undergoing chemoradiotherapy-a pilot prospective cohort study.

ABSTRACT:

Background

Head and Neck cancers are the fourth most common cancers worldwide with approximately 1.8 million new cases each year. The 5-year relative survival rates have increased significantly for most cancers in Australia, however, some head and neck cancers including laryngeal and lip cancers have shown no significant change over time. Therefore, there is an urgent need to identify novel prognostic biomarkers to tailor the treatment. MicroRNAs (miRNAs) are endogenous, short, non-coding single-stranded RNAs that regulate gene expression at the post-transcriptional level, controlling a wide range of biological and pathological processes. Increasingly, associations between miRNA and cancer diagnosis, prognosis, and treatment response have been reported. In this study, we investigat

SUBMITTER: Lamichhane SR 

PROVIDER: S-EPMC12554481 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature