Development and validation of a lipid metabolism-related prognostic model for gastric adenocarcinoma.

ABSTRACT:

Background

Lipid metabolism plays a critical role in the development, progression, and immune regulation of gastric adenocarcinoma (GA). However, its prognostic significance and relationship with the tumor microenvironment (TME) remain unclear. This study aimed to construct a GA lipid metabolism-related prognostic model and evaluate its clinical relevance in GA.

Methods

Lipid metabolism-related differentially expressed genes (DEGs) were identified from The Cancer Genome Atlas (TCGA) database. A prognostic lipid metabolism-related signature for GA (GA-LMRS) was developed via least absolute shrinkage and selection operator (LASSO) and Cox regression analyses. The model's predictive performance was validated in multiple cohorts. Functional enrichment, tumor mutation burden (TMB

SUBMITTER: Li Q 

PROVIDER: S-EPMC12554482 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature