Establishment of a prognostic model and immune profiling based on phagocytic regulatory genes in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a prevalent and highly aggressive malignancy. Phagocytic regulatory factors (PRFs) play a crucial role in regulating the progression of HCC. This study aimed to investigate the prognostic and immunological features of HCC based on phagocytic regulatory factor-related genes (PFRGs).

Methods

The single-sample gene set enrichment analysis (ssGSEA) was employed to evaluate the enrichment scores of PFRGs in the The Cancer Genome Atlas (TCGA)-Liver Hepatocellular Carcinoma (LIHC) cohort. Univariate, least absolute shrinkage and selection operator (LASSO), and multivariate regression analyses were conducted to identify prognostic feature genes. The prognostic performance of the risk model was evaluated using receiver operating characteri

SUBMITTER: Meng X 

PROVIDER: S-EPMC12554488 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature