Development and validation of a necroptosis-related gene signature for predicting prognosis and immune infiltration in papillary thyroid cancer.

ABSTRACT:

Background

Papillary thyroid cancer (PTC) accounts for over 80-85% of all thyroid malignancies and presents a rising global incidence. Necroptosis plays a pivotal role in oncogenesis and immune regulation. However, the prognostic relevance of necroptosis-related genes (NRGs) in PTC remains inadequately explored. This study aims to construct a prognostic model for PTC based on NRGs and evaluate its predictive value for the prognosis of PTC patients.

Methods

Using data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO), prognostic-related genes (PRGs) were screened via univariate Cox analysis and subsequently refined using least absolute shrinkage and selection operator (LASSO) regularization. Gene set enrichment analysis (GSEA) was then performed for ea

SUBMITTER: Wang S 

PROVIDER: S-EPMC12554494 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature