Establishment and characterization of two patient-derived cell lines from a patient with gallbladder carcinoma.

ABSTRACT:

Background

The patient-derived primary cell line (PDC) exhibits similar biological characteristics to the original tumor tissue, and is a unique translational medicine tool for studying the growth, differentiation, metastasis and drug sensitivity of malignant tumor cells. However, due to the limited number of PDC models of gallbladder cancer (GBC) and the high genetic heterogeneity of GBC, it is necessary to establish PDC models representing different types of GBC patients. The aim of this study is to establish GBC PDCs and characterize their biological features, which can be used as in vitro preclinical models for GBC.

Methods

Two PDCs were developed from one patient with GBC (JXQ-3D-1404R1 and JXQ-3D-1404R2). The two cancer cell lines were characterized with respect

SUBMITTER: Feng F 

PROVIDER: S-EPMC12554496 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature