Neochlorogenic acid inhibits gastric cancer cell growth through apoptosis and cell cycle arrest.

ABSTRACT:

Background

Gastric cancer is a leading cause of cancer-related deaths worldwide. It remains a significant clinical challenge due to its frequent diagnosis at advanced stages and the development of resistance to conventional therapies. Neochlorogenic acid (NCA) is a phenolic compound with reported anti-inflammatory, antioxidant, and anti-tumor properties. This study aims to elucidate the mechanisms underlying NCA's anti-tumor effects in gastric cancer.

Methods

In vitro, HGC-27 and NUGC-3 cells were treated with NCA. The half maximal inhibitory concentration (IC50) values of the two cells at 48 hours after drug treatment were 229.9 and 130.0 µM, respectively, and cell proliferation, migration, cell cycle, and apoptosis were evaluated. Western blot analysis was used to a

SUBMITTER: Sun W 

PROVIDER: S-EPMC12554510 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature