Immunogenomic classification and nomogram development and validation for colorectal cancer survival prediction based on immune-related genes.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common digestive cancer, and immunity plays an important role in the development of CRC. In this study, we aimed to explore immune-related prognostic biomarkers.

Methods

We first explored the immune microenvironment and identified a high immune score cluster and a low immune score cluster on the basis of the immune score calculated by single-sample gene set enrichment analysis (ssGSEA). We also explored the differentially expressed genes (DEGs) between the high- and low-immune score groups and utilized weighted gene coexpression network analysis (WGCNA) to explore the gene sets with the highest correlation with prognosis. DEGs between paracancerous and tumor tissues were discovered on the basis of the RNA sequencing result

SUBMITTER: Shen G 

PROVIDER: S-EPMC12554512 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature