A nomogram for predicting overall survival in advanced hepatocellular carcinoma patients receiving radiotherapy combined with targeted therapy: a multicenter retrospective study.

ABSTRACT:

Background

Although radiotherapy (RT) combined with targeted therapy has emerged as a viable treatment for advanced hepatocellular carcinoma (HCC), predicting survival outcomes remains difficult. This study aimed to develop and validate a prognostic model integrating clinical parameters to predict overall survival (OS) in patients with advanced-stage HCC receiving RT combined with targeted therapy.

Methods

A total of 248 advanced HCC patients treated with intensity-modulated RT (IMRT) combined with targeted therapy were retrospectively enrolled from three tertiary hospitals in China and randomly divided into training (n=148) and validation (n=100) cohorts. Least absolute shrinkage and selection operator (LASSO) regression followed by multivariable Cox analysis was used to id

SUBMITTER: Liu X 

PROVIDER: S-EPMC12554517 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature