Assessment of the influence of vitamin D in patients with sepsis: a systematic review and meta-analysis.

ABSTRACT:

Background

This systematic review and meta-analysis seeks to extensively estimate the interrelation between vitamin D (VD) and clinical results among both pediatric and adult sepsis patients.

Methods

A search was implemented through four databases (PubMed, Embase, Cochrane Library, and Web of Science) up to February 2025. Meta-analysis was implemented utilizing Stata 15 and Meta-Disc software.

Results

Thirty-nine studies were included, encompassing 1,208 pediatric and neonatal sepsis patients, and 60,566 adult sepsis patients. The results showed that the average VD level in neonates with sepsis was 12.99 (95% CI: 8.11, 17.87), and the average VD level in children was 24.84 (95% CI: 21.34, 28.33). Their VD levels were considerably lower relative to healthy individuals

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12554583 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature