The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels.

ABSTRACT:

Background

The associations between the rs7799039 variant in the promoter region of the leptin gene (LEP) and the rs1137100, rs1137101, and rs1805094 variants in the exons of the leptin receptor gene (LEPR) with leptin levels and glucose-lipid metabolism markers have been examined across various populations. However, the findings have been inconsistent and, at times, contradictory.

Methods

Eligible studies were identified through a search of PubMed, Google Scholar, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases. A random-effects model was employed, and the standardized mean difference (SMD) with 95% confidence interval (95% CI) was calculated to assess the differences in leptin levels and glucose-lipid metabolism markers between subj

SUBMITTER: Song Y 

PROVIDER: S-EPMC12554595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature