The role of cytochrome P450 genetic variants in pesticide metabolism and the risk of child neurodevelopment: a systematic review.

ABSTRACT:

Introduction

Child neurodevelopment is influenced by genetic variants in cytochrome P450 (CYP450) enzymes, which affect detoxification and oxidative stress pathways. These variations modulate susceptibility to environmental toxins, influencing brain development through gene-environment interactions that impact neurogenesis, synaptogenesis, and inflammation, potentially contributing to neurodevelopmental disorders. This review has a major question to answer: how do CYP450 gene polymorphisms modulate pesticide metabolism and contribute to neurodevelopmental risks in children?

Method

This study has been conducted according to PRISMA and includes studies conducted from 2005 to 2025. It has been registered to PROSPERO with the number PROSPERO 2024 CRD42024617478. The databases us

SUBMITTER: Chilipweli PM 

PROVIDER: S-EPMC12554605 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature