Age-related obesity and inflammaging in cats.

ABSTRACT: Aging is characterized by chronic systemic inflammation accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. A chronic low-grade pro-inflammatory state known as "inflammaging" accelerates age-related diseases such as obesity, diabetes, vascular diseases, and certain types of cancer. Senescent cells drive age-related tissue dysfunction partially by inducing a chronic senescence-associated secretory phenotype (SASP) associated with various diseases. Obesity and insulin resistance change with advancing age and are linked to low-grade chronic inflammation, leading to age-related diseases. Obesity results in significant changes in the adipokine profile, such as reduced levels of anti-inflammatory adipokines, e.g., adiponectin. Cats are more prone to

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC12554617 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature