Kinship Decouple and Phenotype Selection (KDPS): a tool for phenotype-aware decoupling of related subjects.

ABSTRACT: Relatedness within genomic cohorts is a potential source of bias for many genetic analyses. Existing tools to break relatedness are phenotype-naïve; they indiscriminately remove subjects to break relationship, risking the loss of valuable data, especially in studies targeting uncommon and rare phenotypes. To address this limitation, we developed the Kinship Decouple and Phenotype Selection (KDPS) tool, with a novel algorithm designed to enhance the precision of subject selection in genetic and epidemiological research by incorporating phenotype prioritization. KDPS separates related individuals by considering relatedness (kinship or identity by descent) scores and allows prioritizing subjects based on phenotypes of interest. This approach enables the retention of valuable subjects for anal

SUBMITTER: Gu W 

PROVIDER: S-EPMC12554634 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature