Metabolic-immune crosstalk in myocardial infarction: RLF and SMCHD1 identified as causal therapeutic targets via integrated lactylation-MR analysis.

ABSTRACT:

Background

The diagnosis of Myocardial Infarction (MI) requires the discovery of specific diagnostic biomarkers beyond high-sensitivity cardiac troponins. To identify causal MI-associated genes regulated by lactylation modification and elucidate their roles in metabolic-immune dysregulation.

Methods

This multi-omics study combined bioinformatic analyses of human MI datasets (GSE60993/GSE61144/GSE66360) with experimental validation to investigate lactylation-related genes (LRGs). Differential expression analysis (limma, P < 0.05, |log₂FC|>0.585) identified 571 Differentially Expressed Genes (DEGs), which intersected with 2,051 curated lactylation-related genes (LRGs) (PubMed/GeneCards) yielding 56 lactylation-associated DEGs. Mendelian randomization (MR) utilized g

SUBMITTER: Tang J 

PROVIDER: S-EPMC12554677 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature