Clonal transmission and species-specific mechanisms of polymyxin resistance in carbapenem-resistant <i>Enterobacteriaceae</i> from Southwest China.

ABSTRACT:

Objectives

The rapid dissemination of carbapenem-resistant Enterobacteriaceae (CRE) poses a severe global health threat due to limited treatment options. Polymyxin is currently considered a last-resort therapy for human infections caused by CRE. The increasing clinical use of polymyxin has resulted in alarming resistance rates. This study investigated the clinical characteristics, molecular epidemiological characteristics, and resistance mechanisms of polymyxin-resistant CRE (PR-CRE) in Chongqing, China.

Methods

Antimicrobial susceptibility and resistance genes were analyzed by PCR-based amplification and sequence analysis. Molecular epidemiological characteristics were analyzed using Enterobacterial Repetitive Intergenic Consensus (ERIC)-PCR and multilocus sequence t

SUBMITTER: Si T 

PROVIDER: S-EPMC12554700 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature