Evaluating the risk of osteopenia-related adverse events with antiepileptic drugs: a pharmacovigilance study based on the FAERS database.

ABSTRACT:

Background

Controversy remains regarding the association between antiepileptic drugs and osteopenia, and this study aims to investigate and address this gap using real-world data.

Materials and methods

This study included data from the United States (U.S.) Food and Drug Administration Adverse Event Reporting System (FAERS) from the first quarter of 2005 to the first quarter of 2025. A disproportionate analysis method and Bonferroni-corrected p-value were used to detect association signals between antiepileptic drugs and osteopenia. Additionally, subgroup analyses were conducted to explore differences among different age and gender groups.

Results

Among the 206,680 adverse events associated with 12 commonly used antiepileptic drugs recorded in the FAERS database during

SUBMITTER: Yang N 

PROVIDER: S-EPMC12554713 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature