Characterization of the airway microbiome in preterm infants with bronchopulmonary dysplasia.

ABSTRACT:

Background and aims

Bronchopulmonary dysplasia (BPD) represents a persistent respiratory condition that primarily affects preterm infants, distinguished by abnormal lung development and function. Previous studies have indicated a significant association between the pulmonary microbiome and various respiratory diseases. This study aimed to compare the airway microbiome composition and its temporal changes in preterm infants with and without BPD.

Methods

We conducted a cohort study involving 14 infants diagnosed with BPD and 10 preterm infants without BPD, all born at a gestational age (GA) < 32 weeks. Tracheal aspirates were collected on day 1 during intubation, as well as on days 7 and 14 following the intubation procedure. Subsequently, bacterial DNA was extracted, and the

SUBMITTER: Bao Z 

PROVIDER: S-EPMC12554745 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature