Sophora tonkinensis enhances activation of cGAS-STING pathway and restrains HBV replication.

ABSTRACT:

Background

Cyclic GMP-AMP synthase (cGAS)-Stimulator of interferon genes (STING) signaling pathway plays a vital role in innate immune response. Once activated, cGAS-STING pathway mediates the production of type I IFNs and pro-inflammatory cytokines, triggering antiviral response. The Chinese medicine Sophora Tonkinensis Gagnep. is a commonly used traditional Chinese medicine with the effects of clearing away heat and detoxification, subduing swelling and relieving pharynx. Modern studies have shown that it has antiviral activity, however, its mechanism of action is still not clear.

Methods

In this study, we used the botanical drug Sophora tonkinensis Gagnep. (Fabaceae) and investigated the effect of Sophorae tonkinensis extract (STE) on the activation of the c

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12554753 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature