Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice.

ABSTRACT:

Introduction

Biological aging and sex interact to shape systemic metabolism, yet their role in chronic pain resolution remains unexplored. We hypothesized that metabolic resilience-the ability to flexibly switch fuel sources and maintain energy homeostasis-rules successful recovery from nerve injury in a sex-dependent manner during aging.

Methods

In 12-month-old male and female mice, corresponding to the perimenopausal phase in females and the onset of hormonal decline in both sexes, we induced sciatic nerve chronic constriction injury and performed multi-omics profiling during Wallerian degeneration, a phase known to trigger long-term neurobiological remodeling.

Results

Aging females exhibited early activation of fatty acid oxidation, increased resting energy expendi

SUBMITTER: Marinelli S 

PROVIDER: S-EPMC12554762 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature