Acute blood loss anemia aggravates endothelial dysfunction after acute myocardial infarction.

ABSTRACT:

Background

Anemia is frequently observed in patients with acute myocardial infarction (AMI) and is known to be associated with poor prognosis. We recently demonstrated that acute blood loss anemia is associated with a compensatory increase in endothelial nitric oxide (NO)-dependent flow-mediated dilation (FMD) responses. However, the effects of acute anemia on systemic endothelial function after AMI remain unclear. In this study, we evaluated systemic endothelial function following AMI in an established murine model of acute blood loss anemia. We hypothesize that acute anemia aggravates systemic endothelial dysfunction (ED) after AMI.

Methods and results

Acute anemia was induced in male C57BL/6J mice by repeated blood withdrawal for three consecutive days. Separate groups of

SUBMITTER: Solga I 

PROVIDER: S-EPMC12554764 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature