SARS-CoV-2 vaccines induce a diverse spike-specific CD4+ T cell receptor repertoire in people living with HIV with low CD4 nadirs.

ABSTRACT: People living with HIV with low CD4 T cell nadirs on antiretroviral therapy have suboptimal responses to immunization. We analyzed the SARS-CoV-2 spike-specific CD4+ T cell repertoire in individuals with CD4 nadirs of less than 100 cells/ul who received a primary SARS-CoV-2 mRNA vaccine series as well as the bivalent ancestral/BA.5 spike mRNA vaccine. We tested the hypothesis that antigenic imprinting would result in the preferential expansion of pre-existing cross-reactive T cells that were primed against the 4 common cold coronaviruses. We found that these individuals made robust effector and memory T cell responses to the SARS-CoV-2 spike protein that exceeded the responses to spike proteins from the common cold coronaviruses. Furthermore, in 4 individuals, the number of SARS-CoV-2 spec

SUBMITTER: Mercado A 

PROVIDER: S-EPMC12554773 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature