First identification of human adenovirus subtype 21a in Shenzhen, China with high-throughput sequencing.

ABSTRACT: Human adenovirus type 21 (HAdV-21) is recognized as an important pathogen responsible for acute respiratory infections (ARIs). However, it has been rarely reported and remains poorly characterized to date in China. Outpatient or inpatient children under 14 years old with suspected ARIs were enrolled from two hospitals in Shenzhen from September 2023 to April 2024. Respiratory samples were collected and tested for 22 common respiratory pathogens. A comparative analysis was conducted on the positive proportions of pathogens among different groups. Phylogenetic analysis and amino acid mutation analysis were conducted for HAdV-21 strains. A total of 498 pediatric patients with ARIs were enrolled. There were 366 (73.5%) patients infected with at least one pathogen, and 133 (26.7%) patients co-i

SUBMITTER: Niu DD 

PROVIDER: S-EPMC12554774 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature