The Precuneus Region Drives Brain Network Changes in Tremor-Dominant Parkinson's Disease: Insights from a Morphological Causal Analysis.

ABSTRACT: The tremor-dominant (TD) subtype of Parkinson's disease (PD) is characterized by prominent tremor symptoms. However, the temporal and causal relationships between brain structural alterations in TD patients remain unexplored. A total of 61 TD patients and 61 matched healthy controls (HCs) were included in this study. The gray matter volume (GMV) of the bilateral precuneus (PCUN) was significantly reduced in TD patients. A structural covariance network analysis seeded with the left pallidum (PAL.L), which had the most significant differences, revealed a substantial reduction in covariance with precentral gyrus in TD patients. We performed a causal structural covariance network analysis using the TD duration as a pseudotime series. The PCUN, with the highest out-degree in the cortex, regulat

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12554785 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature