Social support moderates the impact of neighborhood disadvantage on serum cortisol levels in post-surgical breast cancer patients.

ABSTRACT:

Introduction

Neighborhood disadvantage generates chronic adversity and negatively impacts breast cancer (BCa) survival. Greater social support may correspond with less adversity in BCa patients via physiological stress mechanisms. We evaluated the association between neighborhood disadvantage and serum cortisol, a physiologic marker of stress, and whether social support moderates this relationship in BCa patients.

Methods

Women diagnosed with stage 0-III BCa post-surgery and before adjuvant treatment provided a late afternoon-evening serum cortisol sample and completed the Social Provisions Scale (SPS). Area Deprivation Index (ADI), a validated measure of neighborhood disadvantage, was determined using home addresses. Multivariable regression tested the relationship between

SUBMITTER: Hernandez AE 

PROVIDER: S-EPMC12554796 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature