Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis.

ABSTRACT: Statins are effective drugs for lowering hypercholesterolemia and preventing cardiovascular diseases. They can cause various side effects, in particular statin-associated muscle symptoms (SAMS) associated with mitochondrial dysfunction and micronutrient depletion. The aim of this systematic review and meta-analysis was to investigate the efficacy of a supplementation with Coenzyme Q10 (CoQ10) against SAMS in statin-treated patients. A systematic literature search was performed in Medline and Cochrane Library in August 2024. Studies were selected for a meta-analysis according to the following criteria: randomised controlled trials (RCTs), adults taking statins (any type and dose), supplementation of CoQ10, a comparable control group, and muscle pain as outcome criterion. Cochrane Risk of Bi

SUBMITTER: Kovacic S 

PROVIDER: S-EPMC12554813 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature