Central Nervous System-Active Medications and Risk of Hospital Readmission in Older Multimorbid Adults.

ABSTRACT:

Background

Polypharmacy is associated with adverse outcomes, particularly in older multimorbid adults. However, little is known about the negative outcomes associated with multiple central nervous system (CNS)-active medications that are commonly prescribed to these patients.

Objective

To assess the association between the number of CNS-active medications at discharge and the risk of 1-year all-cause hospital readmission, drug-related hospital readmission (DRA), death, quality of life (QoL) and functional status in older multimorbid adults.

Methods

Among 2008 older multimorbid inpatients with polypharmacy, we assessed the association between the number of CNS-active medications and 1-year all-cause hospital readmission, DRA, and death by Cox proportional hazard models

SUBMITTER: Stuber MJ 

PROVIDER: S-EPMC12554834 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature