RGD-grafted dextran methacrylate hydrogel incorporating osteogenic peptide and Mn₃O₄ nanozymes for enhanced bone defect healing.

ABSTRACT: Aggressive inflammation triggered by excessive reactive oxygen species (ROS) seriously disrupts intercellular communication between macrophages and tissue regenerative cells, such as bone marrow mesenchymal stem cells (BMSCs) and vascular endothelial cells, thereby delaying the healing process. Modulating the immune microenvironment through biomaterial-based strategies is crucial for effective healing. In this study, we constructed a composite hydrogel (denoted as RGD@DEXMA/DOPA-P24/Mn₃O₄) by co-loading manganous-manganic oxide (Mn₃O₄) nanozyme and 3,4-dihydroxyphenylalanine-modified osteogenic peptide P24 (DOPA-P24) into arginine-glycine-aspartic acid (RGD)-grafted dextran methacrylate (DEXMA) hydrogel. The Mn₃O₄ nanozymes

SUBMITTER: Pang Y 

PROVIDER: S-EPMC12554889 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature