Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Macrophages contribute to the immune dysregulation observed in chronic obstructive pulmonary disease (COPD). Additionally, lactylation exerts an indirect influence on COPD pathogenesis. However, the specific biomarkers linked to macrophage activation in COPD and the underlying molecular mechanisms remain poorly understood. This study aimed to identify these biomarkers and elucidate the associated molecular pathways.

Methods

Data were retrieved from public databases. A comprehensive analysis was conducted using weighted gene co-expression network analysis (WGCNA), immune infiltration analysis, differential expression analysis, correlation studies, machine learning, receiver operating characteristic (ROC) analysis, and expression level validation to identify macroph

SUBMITTER: Guo H 

PROVIDER: S-EPMC12554970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature