Identification of Hasegawa Dementia Scale-Revised Cutoff Scores Associated With Mini-Mental State Examination Thresholds for Anti-Amyloid β Therapies in Patients With Amnesia.

ABSTRACT:

Background

This study aimed to evaluate Hasegawa Dementia Scale-Revised (HDS-R) cutoff scores that correspond to Mini-Mental State Examination (MMSE) thresholds for identifying candidates for anti-amyloid β (Aβ) therapies. Additionally, we conducted exploratory analyses to examine the cognitive subdomains associated with Aβ status.

Methods

This retrospective cross-sectional study included consecutive patients with amnesia who underwent neuropsychological examinations and Aβ assessment through cerebrospinal fluid analysis or positron emission tomography. Diagnostic accuracy for MMSE thresholds (≥ 20, ≥ 22 and ≥ 24) was assessed, and two HDS-R cutoffs (high-sensitivity, high-specificity) were determined for each threshold. We examined differences in cognitive subdomains betwee

SUBMITTER: Yamakami K 

PROVIDER: S-EPMC12555022 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature