Age-Matched Reference Values for Circulating Natural Killer T (NKT)-Like Cells.

ABSTRACT: Natural Killer T-like cells are T lymphocytes characterised by the expression of CD56 accompanied by perforin and granzyme B production, typical of cytotoxic cells and the innate immunity compartment. Imbalance in their distribution could occur in pathological conditions, including solid or haematological cancers, autoimmune disorders and metabolic diseases; therefore we aimed to define age-matched reference values of the NKT-like population. NKT-like cell count and their expression of CD4 and CD8 surface antigens were evaluated in 2208 subjects by flow cytometry, with a lyse-no-wash protocol in a CE-IVD workup. Outpatients without alteration of any laboratory test and adult healthy volunteers were used to determine NKT-like age-matched reference values; a total of 490 subjects divided int

SUBMITTER: Trombetta E 

PROVIDER: S-EPMC12555025 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature