Veratramine influences the proliferation of human osteosarcoma cells through modulating the PI3K/AKT signaling cascade.

ABSTRACT: Osteosarcoma (OS) is a highly aggressive tumor with a propensity for early metastasis. Current treatment methods, such as chemotherapy, often bring significant side effects, affecting patients' quality of life. Veratramine (VER), an alkaloid derived from the American lily plant, has shown potential in cancer treatment. This study looks at the effects and mechanisms of VER on osteosarcoma. VER's impact was assessed using a variety of procedures, including crystal violet staining, the CCK-8 assay, and the colony formation assay, which measured cell proliferation. Wound healing assay and transwell assay were employed to evaluate the migration and invasion of osteosarcoma cells. Hoechst33258 staining, flow cytometry, and transmission electron microscopy were used to investigate apoptosis. Prot

SUBMITTER: Xie Z 

PROVIDER: S-EPMC12555783 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature