Isotype-selective roles of hepatic acetyl-CoA carboxylases in a mouse model of fatty liver disease.

ABSTRACT:

Objectives

Acetyl-CoA carboxylase enzymes ACC1 and ACC2 promote liver fat storage. Accordingly, ACC inhibition represents a strategy to reverse fatty liver disease and related disorders. Human and rodent studies show that targeting both ACC isotypes can reverse some fatty liver phenotypes, but also result in unwanted metabolic phenotypes including hypertriglyceridemia. The objective of this study was to determine whether liver-selective genetic inhibition of ACC1 or ACC2 individually can reverse fatty liver disease phenotypes without adverse metabolic phenotypes in a mouse model of fatty liver disease.

Methods

Four genotypes of male C57BL/6J mice floxed for ACC1, ACC2, both ACC alleles, or no ACC alleles were fed an Amylin diet for 28 weeks to induce fatty liver disease. Aft

SUBMITTER: Beretta M 

PROVIDER: S-EPMC12555813 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature