Cortical GABAergic Neuron Dysregulation in Schizophrenia Is Age Dependent.

ABSTRACT:

Background

Cortical GABAergic (gamma-aminobutyric acidergic) neuron dysregulation is implicated in schizophrenia (SCZ), but it remains unclear whether these changes are due to altered cell proportions or per-cell changes in messenger RNA (mRNA) expression.

Methods

We analyzed 14 bulk and cell type-specific RNA sequencing (RNA-seq) datasets from 1408 individuals (672 SCZ cases, 736 controls) across 3 neocortical regions. We deconvolved GABAergic cell-subtype proportions from bulk RNA-seq and benchmarked them against single-nucleus RNA-seq and stereological densities from matched donors. We assessed SCZ- and age-associated changes in cell proportions and per-cell gene expression.

Results

SCZ was associated with altered proportions of neocortical parvalbumin (PVALB) and

SUBMITTER: Kiss D 

PROVIDER: S-EPMC12556227 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature