Trends of serotypes and resistance among Streptococcus pneumoniae in the UK and Ireland (1999-2019).

ABSTRACT:

Objectives

This study aimed to report the serotype distribution of Streptococcus pneumoniae isolates from UK and Irish patients with bacteraemia or community-associated lower respiratory tract infections (CA-LRTI). Depending upon the year, these were from 23 to 39 sentinel laboratories and were collected between 1999 and 2019, thus spanning the introduction of pneumococcal conjugate vaccines, PCV7 and PCV13.

Methods

Pneumococcal identification, susceptibility testing and serotyping were undertaken by a central laboratory. Changes in serotype distributions and among the predominant types showing antibiotic non-susceptibility were reviewed in relation to vaccine deployment.

Results

Following the introduction of PCV7 (2006) and PCV13 (2010), major shifts occurred in sero

SUBMITTER: Horner C 

PROVIDER: S-EPMC12556646 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature