Prognostic role and mutational characteristics of N6-methyladenosine-related genes in lung adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) is an invasive disease that originates from small airway epithelial cells or alveolar type II cells. Abnormal N6-methyladenosine (m6A) RNA methylation serves a key role in the pathogenesis of human diseases, including cancer. RNA sequencing and somatic mutation data in the Genomic Data Commons (GDC) and The Cancer Genome Atlas (TCGA)-LUAD were downloaded from University of California, Santa Cruz (UCSC) Xena database for a comprehensive analysis. m6A-related genes were selected from the content of RNA m6A modification in cancer. m6A genes were further screened by comparing how m6A genes affected survival in normal and tumor groups and analyzing the relationship between m6A genes and LUAD. GDC LUAD data were downloaded from the UCSC Xena public database to analyze

SUBMITTER: Yang J 

PROVIDER: S-EPMC12557285 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature