A novel defined cuproptosis-related signature score to predict prognosis and immunotherapy efficacy in pancreatic cancer.

ABSTRACT: Cuproptosis, a novel mode of copper-dependent programmed cell death, represents a distinct mechanism separate from other established forms of cell death. The present study aimed to explore the intertumoral heterogeneity of cell death and its relationship with the tumor microenvironment (TME) in pancreatic cancer (PC). Multiple bioinformatics approaches, using multi-omics data from The Cancer Genome Atlas, Genome Tissue Expression, International Cancer Genome Consortium, Gene Expression Omnibus and Clinical Proteomic Tumor Analysis Consortium datasets, and in vitro validation were employed to comprehensively analyze the expression profile, prognostic value and immune cell infiltration of cuproptosis-related genes (CGs) in PC. The enrichment scores of five reported cell death modes we

SUBMITTER: Ge W 

PROVIDER: S-EPMC12557288 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature