Real-Time Optical and Acoustic Characterization of Phase-Shift Droplets for Drug-Delivery Applications.

ABSTRACT: Phase-shift droplets undergoing acoustic droplet vaporization (ADV) offer a promising approach for ultrasound-mediated drug delivery, enabling the spatiotemporally controlled release of therapeutic payloads. A comprehensive understanding of their behavior, through both optical and acoustic methods, is essential for optimizing the therapeutic efficacy. In this study, we investigated the effects of driving pressure, pulse duration, and bulk boiling point of perfluorocarbon droplets on ADV dynamics, payload release, and acoustic emissions. We employed ultra-high-speed brightfield [10 million frames per second (Mfps)], fluorescence (2 Mfps), and confocal microscopy (1 fps) to capture ADV and real-time payload release in fibrin-based hydrogels. During ADV, payload release velocities reached 2-4

SUBMITTER: Abeid BA 

PROVIDER: S-EPMC12557304 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature