Acoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery.

ABSTRACT: Hydrogels can serve as local drug delivery depots that protect the biological activity of labile therapeutics. However, drug release from conventional hydrogels is typically rapid, which is not ideal for many therapeutic agents. We developed a composite hydrogel that enables sustained drug release in response to ultrasound. The composite, termed an acoustically responsive scaffold (ARS), consists of a fibrin hydrogel and a phase-shift emulsion. Upon exposure to ultrasound, the emulsion is vaporized into bubbles, which leads to release of drugs contained within the emulsion. Previously, ARSs have been used in regenerative applications to stimulate blood vessel growth. Here, we characterize the release kinetics and mechanisms of ARSs. Release exhibits a triphasic pattern compromising a slow

SUBMITTER: Xiao H 

PROVIDER: S-EPMC12557307 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature