Sustainable multicomponent synthesis of C-4 sulfenylated pyrazoles <i>via</i> sodium thiosulfate-promoted tandem cyclocondensation and C-H sulfenylation.

ABSTRACT: We report a novel and environmentally benign multicomponent reaction (MCR) strategy for the synthesis of C-4 sulfenylated pyrazoles promoted by Na₂S₂O₃·5H₂O. This metal-free, one-pot protocol enables the simultaneous formation of two C-N bonds and one C-S bond through a cascade of cyclocondensation and direct C-H sulfenylation. A wide range of aryl and alkyl hydrazines and disulfides are efficiently converted to the corresponding products in good to excellent yields (72-94%) under sustainable conditions. DMSO plays a dual role as both the reaction medium and a modulator facilitating thiyl radical generation, which is essential for achieving regioselective C-4 sulfenylation. Compared to previously reported metal-catalyzed methods, this protocol of

SUBMITTER: Abdollahi S 

PROVIDER: S-EPMC12557309 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature