Prognostic value of miR-21 in colorectal cancer, pancreatic ductal adenocarcinoma, and esophageal squamous cell carcinoma: updated systematic review and meta-analysis.

ABSTRACT:

Objective

This study aims to conduct a systematic review of the prognostic value of miR-21 expression levels in patients with colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), and esophageal squamous cell carcinoma (ESCC).

Methods and results

We searched the PubMed, Embase, and CENTRAL databases for relevant studies published up to August 25, 2023. Sixteen studies, totaling 3096 patients, were included. High miR-21 expression was associated with higher hazard ratio (HR) values and decreased overall survival (OS) in CRC and PDAC, but this effect was not statistically significant in ESCC. The pooled HRs for CRC, PDAC, and ESCC were 1.54 (95% confidence interval [CI]: 1.14-2.07; P = 0.004; I2 = 71%), 2.11 (95% CI: 1.81-2.46; P < 0.001; I2 = 0%), and 1.79 (95% CI

SUBMITTER: Huang J 

PROVIDER: S-EPMC12557323 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature