Citric acid cross-linked honey and aloe vera gel loaded chitosan hydrogels for wound dressing applications.

ABSTRACT: Chronic wounds pose a global challenge, often requiring the use of multifunctional materials that facilitate healing while protecting against infection. The present study develops porous, biodegradable and antibacterial composite hydrogels from chitosan and polyvinyl alcohol (PVA) incorporating honey and aloe vera gel as antimicrobial agents for healing chronic wounds. Hydrogels were prepared by freeze gelation methodology, and further crosslinked with citric acid. FTIR spectra confirmed the presence of characteristic functional groups and showed a reduction in the peak intensities of O-H, N-H, and amide bands in crosslinked hydrogels. Scanning electron micrographs illustrated the clear morphological changes; citric acid crosslinked hydrogels (GG-05, GG-06, GG-08) exhibited more porous, sp

SUBMITTER: Shahzad S 

PROVIDER: S-EPMC12557328 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature